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SPR Technology for Biological Mechanism Research
The role of intermolecular interactions in the study of biological mechanism
Organisms contain various types of active molecules such as DNA, RNA, proteins, lipids, and so on. The interaction of these molecules is an important means for organisms to respond to environmental changes and complete cell regulation. They can participate in a variety of physiological activities, including protein function regulation, immune mechanism regulation, disease initiation, signal transduction, gene expression regulation, nuclear transport, membrane vesicle transport, cell migration, and so on. These physiological activities can not only regulate the growth and reproduction of organisms, metabolism, cell apoptosis and necrosis, but also mediate the occurrence and development of tumors, neurodegeneration, viral infections and other diseases. Wrong or dysregulated molecular interactions can cause various pathological phenomena in the human body, such as mutations and methylation. We all know that a cell is composed of thousands of parts, but the combination and strength of these parts are urgently needed for researchers to explore. This is related to the healthy development of human society, because the common enemy that threatens the survival and development of mankind is the current disease.
Surface plasmon resonance (SPR) in the study of biological mechanism
Based on the SPR technology platform for high-throughput and high-precision molecular interaction analysis, SPR can be widely used in biological mechanism research. In addition, the high sensitivity and high selectivity of SPR technology are also advantages that cannot be ignored. The applications of biological mechanism research are as follows.
SPR for Proteomics Research
Proteome research can not only provide a material basis for the laws of life activities, but also provide theoretical basis and solutions for the elucidation and conquering of many kinds of disease mechanisms. SPR technology is mainly used for protein quantification and interaction analysis between protein and other molecules.
SPR for Enzyme Mechanism Research
Enzymes are important substances that regulate the life activities of the human body. When the activity of enzymes is out of regulation, the human body will produce various types of diseases. The essence of enzymes is proteinaceous substances, and our SPR technology platform can explore the regulation mechanisms of different enzymes through high-throughput enzyme-substrate interaction analysis.
SPR for Membrane Protein Research
The life activities of membrane proteins are closely related to cell metabolism. SPR technology can realize the study of pathological mechanisms related to cell metabolism caused by abnormal membrane protein regulation through high-throughput analysis of molecular interactions at the molecular level.
SPR for Structural Biology
The research objects of structural biology are mainly biological macromolecules, including DNA, proteins and so on. Different spatial structures result in huge differences in properties between hierarchical structures due to different conformations. Our SPR technology platform is mainly used for the analysis of complexes and the analysis and interaction analysis between different conformations.
SPR for Neurobiology Mechanism
The investigation of neurobiological mechanism is relatively complicated but it is very meaningful. It mainly focuses on the pathological mechanism of neurological diseases. The most basic research is the analysis of molecular interaction. Our SPR technology platform can achieve high-throughput and high-precision analysis to lay the foundation for subsequent pathological analysis.
SPR for Immunology Mechanism
The research of immunological mechanism has become popular in recent years, because researchers are working on using the endogenous methods of the autoimmune system to fight diseases. Our SPR technology platform can provide help for the immunological mechanisms research at the molecular level to promote the progress of immunological research and the discovery of new methods of related treatments.
SPR for Signal Transduction Mechanism Research
The signal transmission mechanism is the method of communication and communication between cells in a living body. Correspondingly, different signal transduction pathways can regulate different life activities. Signal transduction is a mechanism of absolute specificity and absolute affinity. Our SPR technology platform can perform high-throughput specificity and affinity detection for signal transduction mechanism analysis, and provide suggestions for the discovery of potential targets in the future.
SPR for Cancer Mechanism Research
Cancer is currently one of the main diseases threatening human health. The study of cancer mechanism plays an important role in the early detection of cancer and the discovery of new methods for cancer treatment. Our SPR technology platform can analyze molecular interactions at the molecular level, and screen potential targets for cancer treatment and cancer signature markers.
SPR for Infectious Disease Mechanism
Infectious diseases are often epidemic and contagious. The sooner the mechanism of infection is understood, the faster researchers can develop therapeutic drugs to save more lives. Our SPR technology platform can detect the pathogenesis of infectious diseases and the infectious mechanism in one operation, which greatly promotes the development of infectious disease treatment drugs.
- Last but not least, SPR technology platform is flexible, not only you can choose the standardized chips that we have mass-produced according to your needs, but you can also get chip customization services if your research is more special.
Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.
For research use only. Not intended for any clinical use.