Structural Biology Research Based on SPR Technology

The importance of structural biology research

Structural biology is an interdisciplinary subject that studies the three-dimensional structure, dynamic process and biological functions of biological macromolecules. As shown in the figure below, let us take the spatial structure of DNA as an example. The primary structure of DNA refers to the covalent structure and nucleotide sequence of DNA; the secondary structure of DNA refers to the double helix structure formed by a certain or all nucleotide sequence; the tertiary structure of DNA refers to the chromosomal DNA The complex folded state. Only by forming a spatial structure can the structure of DNA be the most stable and its function can be brought into play.

Fig.1 The spatial structure of DNA

The research of structural biology is the most basic and important research. The main reasons are as follows.

1. Biological macromolecules participate in the exercise of most cell functions

2. Biological macromolecules can only perform their functions when folded into a specific structure

3. The structure of biological macromolecules can directly deepen people's in-depth understanding of functions

4. Drug screening and optimization based on structural information

Combining this structural information with functional research can not only promote people's understanding of the biological functions and molecular mechanisms of biological macromolecules, but also explore the pathogenesis of diseases related to the dysfunction of biological macromolecules.

Surface plasmon resonance (SPR) in structural biology research

Combining this structural information with functional research can not only promote people's understanding of the biological functions and molecular mechanisms of biological macromolecules, but also explore the pathogenesis of diseases related to the dysfunction of biological macromolecules. At the molecular level, the main analytical objects of structural biology analysis through intermolecular interaction analysis are biological macromolecules (proteins and nucleic acids, etc.) and biological macromolecular complexes. The biggest advantage of SPR technology is that it can perform high-throughput analysis of many samples in parallel in one run, which saves the analysis and detection time of large quantities of samples. In addition, the high sensitivity and high selectivity of the technology platform provide high-precision guarantee for your detection process. As shown in the figure below, our SPR technology platform can provide reliable data support for your complex analysis and molecular interaction analysis based on conformational changes, and provide you with a guarantee for further mechanism and pathological research.

Fig.2 BIAchip^TM in the process of structural biology research

Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.

For research use only. Not intended for any clinical use.