Infectious Disease Mechanism Research Based on SPR Technology

The background of Infectious Disease

Infectious diseases are diseases caused by various pathogens that can spread from person to person, animal to animal, or person to animal. Most of the pathogens are microorganisms such as viruses, and a small part are parasites. Usually this disease can be spread through direct contact with infected individuals, the body fluids and excreta of the infected person, and objects contaminated by the infected person. The epidemic of infectious diseases has deeply disturbed human beings. In the history of human struggle with infectious diseases, many infectious diseases that are highly infectious or have a high fatality rate have left a deep impression on people. For example, the new coronavirus, which is currently prevalent in the world, has been epidemic globally for more than 3 years due to its highly contagious nature. Although people continue to be infected with the new coronavirus, the scope of transmission has been greatly reduced, and the number of severe illnesses has been much less. All of this is inseparable from the study of the mechanism of infection of the new crown and the prescription of the right medicine according to the mechanism. The analysis of molecular interaction is an indispensable step in the study of infectious disease mechanisms.

• An example-Intermolecular interaction detection in 2019-nCoV

As shown in the literature below, the detection of intermolecular forces plays an important role in the study of viral infection mechanisms. Researchers explore the binding strength of the new coronavirus and SARS to the receptor body from the molecular mechanism, including both affinity and kinetics. According to the results of the intermolecular affinity test, the binding strength of the new coronavirus to the receptor is 22 times higher than that of the SARS virus. In addition, through kinetic analysis, the rate of dissociation of the new coronavirus after binding to the receptor is slower.

Figure.1 Intermolecular interaction testing is used to reveal why the new coronavirus is more infectious than SARS (Wrapp, D, et al., 2020)

Surface plasmon resonance (SPR) in infectious disease mechanism research

The investigation of the mechanism of infectious diseases, especially the study of the mechanism of infection of unknown infectious diseases, is of far-reaching significance to the healthy development of human beings. If the mechanism of infection can be learned earlier, the corresponding treatment drugs can be developed earlier, so that more deaths of infected people can be avoided. Our SPR technology platform can provide you with high-throughput molecular-level analysis and the specific process is shown in the figure below.

Fig.2 BIAchip^TM in the process of neurobiology mechanism research 

The SPR technology platform can provide you with high-throughput analysis of molecular interactions in the study of infectious disease mechanisms. Faced with different types of infectious diseases with different mechanisms, we provide you with a variety of chips for you to choose according to your needs. When you do not find a suitable chip, our experts will provide you with exclusive customized services. So you don't need to worry about this. Creative Proteomics are sincerely inviting you to try out our SPR services.

In addition to mechanistic studies, antigen-antibody affinity analysis is also very important in the development of drugs for infectious diseases. Our technology platform is also able to perform this task in high throughput.

Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.

For research use only. Not intended for any clinical use.