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SPR Technology for Interaction Analysis in Basic Research
The study of intermolecular interactions is the core of the fields of molecular sciences such as chemistry and biology. It is of great significance for revealing molecular recognition molecular assembly and molecular mechanism of life process, developing high-efficiency chemical sensors, and innovative drugs. Biological responses to environmental changes and cell regulation not only depend on changes in the expression of functional molecules, but also through changes in the strength of interactions. There are various intermolecular interactions in life, such as protein-protein, protein-DNA, protein-carbohydrate, etc. Dysregulated biomolecular interactions lead to the occurrence of various pathological phenomena in humans, animals, plants, and microorganisms, such as mutation and methylation. Therefore, intermolecular interactions play an important role in basic research.
Common molecular interaction technologies and technical characteristics
- Common molecular interaction technologies
1. Yeast two-hybrid
2. Enzyme-linked immunosorbent assay (ELISA)
3. Fluorescence resonance energy transfer (FRET)
4. Co-immunoprecipitation (Co-Ip)
5. Western blotting (Western, Far-Western)
6. Mass spectrometry
7. Chromosomal immunoprecipitation (ChiP, a similar technique to Co-IP)
- Features of common molecular interaction technologies
1. Endpoint technology (Yeast two-hybrid, ELISA, Co-1P, ChiP, Western, MassSpec)
2. Need to mark (Yeast two-hybrid, ELISA, FRET)
3. Detection of strong affinity interactions(ELISA, Co-IP, ChIP, Western, MassSpec)
3. Time-consuming and laborious (ELISA, Western)
4. Inactive or semi-active interactions (ELISA, Western, MassSpec)
5. Less information
Aiming at the common problems in the current molecular interaction analysis methods, our high-throughput surface plasmon resonance (SPR) technology platform can be completely solved.
SPR for Interaction Analysis in Basic Research
Compared with the above commonly used molecular interaction technologies, SPR technology platform has the following advantages.
- Real-time monitoring
- No need to mark
- High sensitivity
- High throughput
- Comprehensive data analysis results
Figure.1 Features of BIAchip™ technology platform
SPR technology platform is a real-time monitoring high-throughput molecular interaction analysis platform, which can provide high-quality molecular interaction analysis services. For customers who choose SPR technology platform in different fields and different experimental requirements, you will be matched with corresponding experts for one-to-one exclusive customized services. Creative Proteomics has been committed to meeting customer needs and reducing waste of customer time.
- Click here to view Analyzable Data Based on SPR system
- Click here to view Analyzable Objects Based on SPR system
You can choose the direction you are interested in from the services provided by SPR technology platform above. If not, please contact us for exclusive customized services. All services of Creative Proteomics are available on a 24/7/365 basis.
For research use only. Not intended for any clinical use.