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SPR Technology for Drug Research Process
The overview of the process of drug research
The drug development process aims to ensure that the designed new drug is effective and safe and can be used by patients in the shortest possible time. As shown in the figure below, the drug development process is tedious and lengthy. The general process is as follows.
Fig.1 New drug development process before clinical research
- The identification of drug targets is the beginning of drug development. Only when the target is determined can all subsequent work have a basis for unfolding. Target determination and target analysis require a large amount of literature research and bioinformatics analysis based on the disease to be treated, including analysis from gene sequence to crystal structure and from genomics to proteomics analysis. The information compiled at this stage is particularly important and will directly influence and guide the entire process of new drug research and development.
- The screening methods of lead drugs include high-throughput screening and computer-aided screening. Lead compound refers to a compound that has preliminary activity to treat a specific target or action link. If a compound can interact with the target, it is expected to change the course of the disease. Then these active compounds will be improved in the later stage. With the improvement of safety and effectiveness, it may eventually become a new drug candidate.
- Drug safety assessment is a necessary step in the development of new drugs, and it is the greatest guarantee for drug safety. Drug safety assessment mainly involves the identification of active ingredients and impurity ingredients.
Surface plasmon resonance (SPR) in the process of drug research process
The SPR technology platform can be widely used in all aspects of the drug development process, and promote the drug development process through high-throughput molecular interaction analysis at the molecular level. The application direction of SPR technology in drug research and development includes the following aspects.
Drug Targets Screening Based on SPR
Target screening of drugs is fundamental to the development and design of new drugs. SPR technology allows for high throughput target screening. Based on our SPR technology platform, your drug development work will be much more efficient and your drug development process will be greatly facilitated.
SPR for development of early diagnosis reagents for diseases
SPR can be applied to the development of early diagnostic reagents through high-throughput intermolecular interaction analysis. The SPR technology platform can guarantee the sensitivity and accuracy of diagnostic reagents and diagnostic kits. Based on the detection and analysis of various biomarker molecules, you can make a preliminary diagnosis of related diseases based on the analysis results.
SPR for development of different drugs
SPR technology has a wide range of applications in the development of different types of drugs, including vaccines, antibody drugs, small molecule drugs, and generic drugs. The SPR technology platform can advance the most cumbersome and time-consuming part of the new drug development process, including high-throughput target screening and lead drug screening.
SPR for drug safety evaluation
Drug safety assessment is the most indispensable step in the drug development process, which is an important guarantee for follow-up drug users. SPR technology can identify the purity of the active substances and impurity substances in the drug through high-throughput concentration analysis. In addition, drug binding activity, such as antibody binding identification, can also be achieved through the SPR technology platforms.
SPR technology can be applied to the part of the drug development process that involves molecular interaction detection, and promotes the entire development process through high-throughput analysis. If you have a need for molecular interaction analysis in the process of drug development, our SPR technology platform can help you better meet your research needs.
Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.
For research use only. Not intended for any clinical use.