Drug Safety Evaluation Based on SPR Technology

The main content and importance of drug safety assessment

Drug safety evaluation is an essential part of the process of new drug research and development, which is the guarantee of drug quality. The three most important characteristics of drugs are safety, effectiveness, and controllable quality. The purpose of drug testing is to prevent unqualified drugs from entering the pharmaceutical market, to ensure the safety of drugs, and to avoid affecting or endangering people's lives and health. In the past, drugs whose safety has not been confirmed have caused life hazards to a large number of drug users. Therefore, the quality and safety assessment of drugs is the most important step in the drug development stage. As shown in the figure below, drug quality and safety testing mainly include the following aspects.  

• Firstly, the drug structure analysis can determine whether the main components of the drug are in line with expectations;
• Secondly, the active substance analysis mainly analyzes the content of the active substance in the drug and the functionality of the active effect;
• Thirdly, the binding activity analysis is mainly used to evaluate the activity of antibody drugs, through the analysis of the active molecules that are actually working in the antibody-antigen binding process.
• Fourthly, impurity analysis is generally mainly used to analyze impurities other than active substances, including unavoidable drug-related impurities and possible contaminants in the production process.

Fig.1 The main content of drug quality assessment

Surface plasmon resonance (SPR) in the process of drug safety assessment

Drug safety assessment involves every stage of new drug development and is an indispensable link. Ensuring the safety of the product at each step is the most basic requirement for the drug development stage. As we show in the figure below, our SPR technology platform is applied to potential drug screening, drug development process, and quality and safety assessment of finished drugs through high-throughput intermolecular interaction detection. Intermolecular interaction analysis mainly involves concentration analysis.

Fig.2 BIAchip^TM in the process of drug safety assessment

In the first part, in the screening stage of potential drugs, SPR technology can conduct structural identification and purity analysis of the potential drugs initially screened to ensure the safety of raw materials.

In the second part, in the drug development stage, because of the various reactions that may occur and the addition of various additives, the SPR technology platform needs to determine the purity of the active ingredients of the drug after each step of the development stage.

In the third part, before the drug becomes a finished drug, it needs to be identified for the active ingredient, the impurity ingredient, and the existence of harmful substances.

The safety assessment part of SPR technology is completely high-throughput, which promotes the drug development process.

Choosing the SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about our SPR platform, please feel free to contact us right now.

For research use only. Not intended for any clinical use.