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Development of Different Drugs Based on SPR Technology
The importance of Intermolecular interaction detection in the process of drug development
With the rapid development of biological technology and the outbreak of various sudden infectious diseases, the research and development of various types of new drugs has increasingly become a research hotspot for researchers. The study of intermolecular interaction occupies an important position in the early stage of drug development, including lead drug screening, drug targeting affinity testing, antigen-antibody analysis and so on. High-throughput molecular interaction research can promote the entire drug development process and promote the development of the pharmaceutical industry.
- Lead compound screening
Drug screening is the first step in the modern drug development process to test and obtain compounds with specific physiological activities. Through molecular interaction, candidate drugs that interact with the target can be screened from the lead compound library or the peptides independently designed and synthesized according to structural biology.
- Drug targeting affinity testing
For drugs developed for specific drug targets, it is necessary to determine the affinity between the drug and the target, and evaluate the drug effect from the affinity and kinetic data. At present, small molecule drugs are quite popular.
- Antigen-antibody analysis
When an antigen binds to an antibody, the antibody does not bind to the entire protein sequence of the antigen, but only binds to a part of the antigen. Therefore, a protein actually contains many different surface sites for antibodies to bind to. When developing certain blocking therapeutic monoclonal antibodies, it is necessary to screen specific epitopes, or to develop monoclonal antibodies with better biological activity against the monoclonal antibodies that have been marketed, the epitope needs to be analyzed.
Surface plasmon resonance (SPR) in the process of drugs development
The SPR technology platform can carry out high-throughput, high-sensitivity and high-selectivity molecular interaction analysis, which is the most suitable choice for the early stage of drug development. SPR technology can be widely used in the research and development process of various drugs, including vaccines, antibody drugs, small molecule drugs, generic drugs, and traditional Chinese medicines.
Vaccine Research
Based on the current status of the global infectious disease pandemic, the demand for vaccines as one of the important means of preventing and controlling infectious diseases is increasing day by day. SPR technology can pass high-throughput protein-related affinity and kinetic tests, shortening the time for vaccine development in molecular interaction analysis, and greatly promoting the development of vaccines.
Antibody Drug Research
SPR technology has two main applications in antibody research, including antibody detection reagents and antibody drug development. Antibodies require high efficiency in the development process. Because the sooner antibody drugs are developed, the fewer people will be protected from sudden infectious diseases. The SPR technology platform, which can realize high-throughput and high-accuracy molecular interaction analysis, plays an important role in the study of molecular mechanisms in the initial stage of antibody development.
Small Molecule Drug Research
How to achieve high-efficiency screening of small molecule drugs is a key research issue in recent years. The SPR technology platform can achieve high-throughput small molecule compound-target affinity and kinetic analysis, and accelerate the process of screening lead compounds from complex compound libraries. SPR technology platform can advance the screening process of drug candidates.
Generic Drug Research
The research of generic drugs is of great significance. There are some special requirements in the process of generic drug research, including the same active ingredients as the original drugs and the active ingredients reaching the standards. Based on high-throughput molecular interaction analysis, SPR technology can be applied to the analysis of the mechanism of action in the early stage and the analysis of the quality standard of active ingredients in the later stage.
Gene Therapy Methods Research
Gene therapy can get to the root of the problem and is the hottest area of research today. Our SPR technology platform provides high-throughput analysis services for the analysis of DNA-related interactions in gene therapy, helping to optimise therapeutic approaches in this field.
Nucleic Acid Drugs Research
Small nucleic acid drugs have now shown great benefits in the treatment of rare diseases. Our SPR technology platform is able to provide high-throughput analysis of small nucleic acid-related interactions for the development of small nucleic acid drugs and to advance the development of small nucleic acid drugs.
Antibody-drug Conjugates Research
Antibody-drug Conjugates are of increasing interest to researchers as an emerging area of research into drug types. Our SPR technology platform can provide high throughput analysis of small molecule and protein-antibody interactions to advance the development of antibody-coupled drugs.
Molecular interaction analysis is an indispensable process in the drug development stage. The SPR technology platform indirectly promotes the drug development process by realizing high-throughput molecular interaction analysis.
Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about our SPR services, please feel free to contact us right now.
For research use only. Not intended for any clinical use.