Vaccine Research Based on SPR Technology

The importance of vaccine research

Vaccination is the most economical and effective public health intervention to prevent and control infectious diseases. Because after vaccination, the probability of contracting infectious diseases will be greatly reduced. Therefore, in the face of sudden infectious diseases, vaccines are time-effective. The faster the vaccine is developed, the faster the infectious disease will be controlled. The development of vaccines is the most important aspect of disease prevention and treatment. Let us take the new coronavirus that is currently raging around the world as an example. With the development of various types of vaccines, the virus situation has temporarily eased. Before these vaccines were developed, due to the rapid spread of the new coronaviru, it has caused many illnesses and deaths on a global scale. The detection of molecular interactions is an essential step in the vaccine development process.

Molecular interaction applications in different kinds of vaccines

As far as the new coronavirus is concerned, the following types of vaccines have been developed.

• Nucleic acid vaccine
• Subunit vaccine
• Nanoparticle vaccine

Regardless of the type of vaccine, in the development stage, the affinity and binding specificity tests of antigens and antibodies are the most necessary steps. Let us take a nanoparticle vaccine as an example. As shown in the figure below, researchers constructed two ferritin nanoparticle vaccines through a series of antigen affinity and binding performance tests. This nanoparticle vaccine can be used as a potential new crown vaccine. Therefore, the efficiency of the detection of intermolecular interactions can reflect the speed of vaccine development to a certain extent. So in terms of vaccine development, i it is very necessary to choose a high-throughput platform for molecular interaction analysis.

Fig.1 Detection of molecular interactions during the development of nanoparticle vaccines( Ma, X, et al., 2020)

Surface plasmon resonance (SPR) in the process of vaccine research

The development process of vaccines mainly involves the detection of protein-related affinity and kinetics. Our SPR technology platform can provide you with customized protein-related chips suitable for various analyses. SPR can not only detect the binding between purified proteins, but also directly detect complex samples such as serum. This will greatly improve the efficiency of your experiments and promote the entire vaccine development process. Time is very precious for vaccine research. The high throughput of our SPR platform can solve this problem, and at the same time the high sensitivity and high selectivity of SPR technology can effectively avoid the problematic data caused by errors. We can provide you with technical support to help your vaccine development process more smoothly.

Fig.2 BIAchip™ in the process of vaccine research 

Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.

For research use only. Not intended for any clinical use.