Virus-related Interactions Analysis Service Based on SPR Technology

Viruses are small and simple in structure, containing only one nucleic acid, and must be parasitic in living cells and replicate non-cellular organisms. A virus is an acellular life form consisting of a long chain of nucleic acid and a protein coat. Viruses do not have their own metabolic machinery, nor do they have an enzymatic system. Therefore, once the virus leaves the host cell, it becomes a chemical substance that has no life activity and cannot reproduce independently. The processes of viral replication, transcription, and translation are all dependent on the host cell. When the virus enters the host cell, it completes its own life activities by using the substances and energy in the cell, and then generates a new generation of virus according to the genetic information contained in its nucleic acid. Studying the interaction between virus and host has very important theoretical significance and practical application value for in-depth understanding of the pathogenic mechanism of virus and finding suitable antiviral solutions. Viruses are a major source of disease, and now we all know that the new coronavirus is raging around the world. The study of the interaction between viruses and host cells is very important for the mechanism of virus infection and the development of antiviral drugs. Firstly, the study of virus infection mechanism can promote the screening of virus targets and lay a theoretical foundation for the formulation of anti-virus programs. Secondly, an in-depth understanding of the pathogenic mechanism of the virus can accelerate the research progress of virus-related prevention and treatment methods, including vaccines, gene therapy, and antiviral drugs. As shown in the figure below, the interaction between the proteome of the virus and the proteome of the human body is relevant to human disease. The analysis of the interaction between virus and host cells not only has very important theoretical significance but also has practical application value.

Fig.1 Schematic diagram of the interaction between the viral proteome and the human proteome (Lasso, G, et al., 2019)

Surface plasmon resonance (SPR) system in the analysis service of virus-related molecular interactions

In the basic research of biomedicine, the interaction analysis between virus and host cell is mainly applied to the study of virus mechanism and the study of virus as a carrier in gene therapy. The study of virus infection mechanism involves complex protein-protein interaction analysis, nucleic acid-protein interaction analysis, and interaction analysis of virus surface and cell surface. When viruses invade host cells, they use complex interactions between biological macromolecules to manipulate cellular processes, including endocytosis, transcription and restricted nuclear transport, protein translation and secretion processes. At the same time, host cells also activate innate antiviral defenses and adaptive immune systems to control virus replication through complex interactions between biological macromolecules. The general flow of our SPR technology platform for virus-cell interaction analysis is shown in the figure below.

Fig.2 BIAchip^TM in the process of virus-related molecular interactions analysis services 

Based on this, our SPR technology platform can provide you with high-throughput virus-related interaction analysis services at the molecular level, saving valuable time for your subsequent virus-related drug development. Let's take viral influenza as an example, if effective drugs can be developed earlier, fewer people will be troubled by infectious diseases. In addition, for your virus-related interaction analysis needs, our platform can ensure high sensitivity of the testing process and high accuracy of testing results. Creative Proteomics can guarantee the reproducibility of the data results, so you do not need to worry about the data of the interaction analysis in the follow-up research process.

Available chip types for virus-related molecular interaction analysis based on SPR

Creative Proteomics has a well-rounded team of professionals and excellence in the field of biochemistry to provide you with fully professional services through our SPR high-throughput technology platform. Every order we receive will be assigned to professionals in the corresponding field to communicate with you one-on-one. The professionalism of our team ensures the efficiency of our service process. After fully understanding your experiment needs, you will receive exclusive customized analysis services within 1-2 days. For virus-related interaction analysis, Creative Proteomics mainly provide the following services.

If you do not find the service you are interested in, please contact us for exclusive customized services. All services of Creative Proteomics are available on a 24/7/365 basis.

For research use only. Not intended for any clinical use.