Tumor Biomarker Detection Service Based on SPR Technology

Tumor markers are substances characteristically present in malignant tumor cells, or produced abnormally by malignant tumor cells, or produced by the host in response to tumor stimulation, which can reflect the occurrence and development of tumors and are used to monitor the response of tumors to treatment. In recent years, with the increasing incidence of tumor patients year by year, tumor markers have become a mandatory test in many people's medical check-ups. Tumor markers are found in blood, cells and tissues and can be measured by chemical, immunological and genomic methods. Tumor marker testing can be used for the following applications.

1. Early detection of tumors
2. Tumor screening
3. Monitoring the efficacy of surgery, chemotherapy and radiotherapy for tumor patients
4. Indicators of tumor recurrence
5. Prognosis determination of tumors
6. Finding the primary foci of metastatic tumors of unknown origin

Tumor markers mainly include proteins, glycans, enzymes and hormones.

Types of tumor markers	Specific Categories
Protein-based tumor markers	Alpha-fetoprotein (AFP) assay Carcinoembryonic antigen (CEA) assay Tissue polypeptide antigen (TPA) assay Prostate-specific antigen (PSA) assay Squamous epithelial cell carcinoma antigen (SCC) assay Cytokeratin 19 fragment (CYFRA 21-1) assay
Glycolipid tumor markers	Cancer antigen 50 (CA50) assay Cancer antigen 724 (CA724) assay Glycogen chain antigen 199 (CA199) assay Carcinoma antigen 125 (CA125) assay Carcinoma antigen 153 (CA153) assay
Enzyme tumor markers	Prostate acid phosphatase (PAP) assay Neuron-specific enolase (NSE) assay
Hormonal tumor markers	Calcitonin (CT) assay

• There are many tumor markers and the sensitivity or specificity of individual markers is often very low. Theoretically, simultaneous measurement of multiple markers is advocated to improve sensitivity and specificity.
• Tumor markers are not the only basis for tumor diagnosis. In clinical practice, a combination of clinical symptoms, imaging and other means is required.
• Some tumor markers may also be abnormally elevated under certain physiological conditions or in certain benign diseases and need to be differentiated.

Surface plasmon resonance (SPR) in the process of tumor biomarker detection

Tumor markers play an important role in the initial screening and prognosis of cancer, and they are important informative molecules in the body that are responsive to tumorigenesis and growth. The study of tumor markers is important for research into mechanisms of tumor cure and new approaches to cancer treatment. According to the general flow chart below, it can be seen that the analysis for tumor markers lies mainly in concentration analysis. While elevated levels of relevant tumor biomarkers in an organism can be used as a basis for initial cancer screening, it is often necessary to combine multiple indicators of multiple markers to make a determination. Creative Proteomics can provide a high throughput technology platform for the analysis of protein-related interactions called SPR. Our SPR technology platform provides molecular interaction analysis services.

Fig.2 BIAchip™ in the process of tumor biomarker detection

SPR technology has many outstanding advantages over traditional interaction analysis service technology platforms, which is the reason you have to choose us.

• Tumor biomarker detection will be available to meet with you on a one-to-one basis as soon as we receive your order in order to fully understand your needs. Due to the flexibility and scalability of SPR technology, it is possible to meet essentially any of your customised needs. This is another important advantage of our technology platform in addition to the high throughput analysis. What's more, the customisation cycle of the chips will not take you too long and you will receive feedback within 1-2 days because of the expertise of our technical and scientific team.
• The high sensitivity of SPR technology facilitates the detection of samples with small molecular weights. Conventional molecular interaction analysis methods generally give weak or almost no signal for the detection of small molecular weight samples. Our SPR technology platform can provide high throughput concentration analysis services to advancetumro mechanism research.

With so many significant advantages for oncentration analysis of tumor biomarkers, why not try our SPR technology platform? Once you have placed your order, Creative Proteomics will arrange for you to receive a tailor-made service from our experts in tumor biomarker field. All services are available on a 24/7/365 basis. If you have any questions or suggestions about our SPR, please feel free to contact us right now.

For research use only. Not intended for any clinical use.