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Protein-related Interactions Analysis Service Based on SPR Technology
Protein is an important component of all cells and tissues of the human body. All the important components of the body need the participation of protein. Protein accounts for about 18% of the total mass of the human body. It is the basic organic matter that constitutes the cell and the main undertaker of life activities. Without protein, there is no life. It is a matter closely related to life and various forms of life activities. Protein is a biopolymer formed by amino acid as the basic unit. Amino acid sequence and spatial folding constitute the diversity of protein structure. Protein has primary, secondary, tertiary and quaternary structure. The structure of a protein determines its function.
Fig.1 The schematic diagram of different levels of protein structure
- Primary structure
The sequence of amino acid residues in the protein peptide chain is called the primary structure of the protein. Every protein has a unique and exact amino acid sequence.
- Secondary structure
The peptide chain in the protein molecule is not linear, but curled (such as α-helix structure) or folded (such as β-sheet structure) according to a certain rule to form a specific spatial structure, which is the secondary structure of the protein. The secondary structure of the protein is mainly achieved by the hydrogen bond formed between the hydrogen atom on the imino (-NH-) of the amino acid residue in the peptide chain and the oxygen atom on the carbonyl group.
- Tertiary structure
On the basis of the secondary structure, the peptide chain further forms a more complex tertiary structure according to a certain spatial structure. Myoglobin and hemoglobin are based on this structure so that the cavity on the surface just accommodates a heme molecule.
- Quaternary structure
The aggregate structure formed by the combination of polypeptide chains with tertiary structure in a certain spatial arrangement is called the quaternary structure of the protein.
Surface plasmon resonance (SPR) technology platform in the analysis service of protein-related molecular interactions
As the most important functional component of the human body, protein research is of great significance to human life activities, disease research and drug development. The various physiological functions of proteins are determined by their complex spatial structures at different levels. This process involves various interactions between proteins and other molecules. Therefore, the analysis of protein-related molecular interactions is very important in basic biological research. If you need protein-related molecular interaction analysis in your project, you can experience the analysis services of our high-throughput SPR technology platform in this regard.
Fig.2 BIAchipTM in the analysis service of protein-related molecular interactions
As we are shown in the figure above, our SPR technology platform can provide efficient protein-related molecular interaction analysis services, which can involve various types of molecules researched in the biological field. Based on the high throughput of SPR technology platform, you don't need to worry about the limitation of the number of samples tested and the repeatability of the experiment. The high throughput of high efficiency can not only improve the efficiency of your protein-related research, but also greatly reduce the cost of your project. In addition, accuracy is the most basic requirement of life science experiments, which is also something that our SPR technology platform can fully guarantee.
- Detectable protein-related molecular interaction analysis of samples based on SPR
Due to the complexity of protein structure, this directly determines the diversity of protein functions. Therefore, the scope of protein-related intermolecular interaction analysis is bound to be diverse. The protein-related molecular interaction analysis of our technology platform can achieve as much as possible the full coverage of protein-related physiological functions. The flexibility of the technology platform provides the basis for the detection of various types of samples, including antibodies, antigens, small organic molecules, bacteria, viruses, tissue lysates, serum, ascites, etc. As long as it is what you can think of or what you need, the technology platform can help you achieve it as much as possible.
- Available chip types for protein-related molecular interaction analysis based on SPR
Creative Proteomics has an outstanding scientific research team and professional-level laboratories, which can provide customized solutions according to your protein-related molecular interaction needs. You can receive feedback on related customized solutions within 1-2 days. The professional ability of the team determines the efficiency of our cooperation process. For protein-related molecular interaction analysis, we provide the following protein-related molecular interaction services.
➢ Protein-protein interaction analysis service
➢ Protein-metal ion interaction analysis service
➢ Protein-small molecule interaction analysis service
➢ Protein-DNA interaction analysis service
➢ Protein-RNA interaction analysis service
➢ Protein-carbohydrate interaction analysis service
If you do not find the service you are interested in, please contact us for exclusive customized services. All services of Creative Proteomics are available on a 24/7/365 basis.
For research use only. Not intended for any clinical use.