Peptidomic Analysis Service Based on SPR Technology

Peptidomics is an important part of proteomics, which is the study of endogenous peptides and low molecular weight proteins in the organism. Peptidomics is the study of the structure, function and changes of the peptidome and their related relationships. There is no clear boundary between peptides and proteins, and proteins with molecular weight less than 10kDa are usually considered as peptides. Peptidomics and proteomics are both complementary to genomics. Peptides can reflect the synthesis, processing and degradation processes of proteins under different physiological and pathological conditions, and at the same time have regulatory effects on the expression of genes, material metabolism and other processes biological activity. Peptides are biologically active substances involved in various cellular functions in the organism, including cytokines, growth hormones and disease-specific degradation fragments of certain proteins in body fluids, etc. They are associated with regulation of the organism, including hormonal regulation, neurotransmitter regulation, cell growth and proliferation regulation, and immune regulation. Peptidomics is therefore considered to be the "bridge" between proteomics and metabolomics. The study of the structure and physiological function of peptides is of great importance in the study of biological mechanisms.

Surface plasmon resonance (SPR) in the process of peptidomic analysis

As small molecular weight proteins, peptides are signalling molecules in a number of important regulatory pathways in the living body and play an important role in the regulation of life activities. When these peptide molecules become abnormal, they can affect normal life activities and even lead to disease. The study of peptidomics is a small branch of proteomics but plays an indispensable role in maintaining the normal activities of living organisms. Peptidomic studies are therefore necessary to investigate biological mechanisms such as hormonal regulation, neuromodulation, cell proliferation and immune mechanisms. The study of peptidomics is based on peptide-related interactions. Therefore, it is important to improve and enhance the methods for the analysis of peptide-related interactions in order to advance the research in peptidomics. If your research project requires peptide-associated interaction analysis, you should consider our high-throughput peptide-associated interaction analysis technology - SPR. The diagram below shows you the general flow of our technology platform for peptidomic analysis.

Fig.1 BIAchip™ in the process of peptidomic analysis

Our SPR technology platform can provide high-throughput peptide-related interaction analysis services that can greatly advance the study of mechanisms related to the physiological activities of living organisms. The high throughput of our technology platform can significantly shorten the cycle time of your biological mechanism research, saving you a lot of time and cost on the one hand and your research project on the other. You do not need to worry about the sensitivity and accuracy of the technology platform. The detection limits are very low and the high sensitivity of the platform facilitates the analysis of low molecular weight peptides. The technology platform is currently used in the following applications, which are listed in the table below.

NO.	Previous applications of SPR	NO.	Previous applications of SPR
1	Identification of peptides expressed in a sample of cells, tissues and body fluids in a given physiological state	5	As a biomarker for novel diseases
2	Neuropeptide/signal peptide research	6	Discovery of natural antibacterial/anti-toxic peptides
3	Cellular antigen epitope prediction	7	Catalytic reaction studies of unknown enzymes in vivo
4	Development of novel peptide drug precursors	8	Mining for new functional peptide molecules

In the table above we have listed some of the peptide related areas where our technology platform can be applied for you to choose from. If there is no area of interest in the table above, you do not need to worry. No matter where you have a need for peptide-related interaction analysis, you can feel free to contact us and we can provide you with a tailor-made service. All services in Creative Proteomics, please keep in touch with us at any time.

For research use only. Not intended for any clinical use.