Nucleic Acid-related Interactions Analysis Service Based on SPR Technology

Nucleic acid is the general term for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is a biological macromolecular compound formed by the polymerization of many nucleotide monomers and is one of the most basic substances of life. Nucleic acid is a type of biopolymer, which is widely present in all animal and plant cells and microorganisms. Nucleic acids are composed of nucleotides, and nucleotide monomers are composed of five-carbon sugars, phosphate groups, and nitrogen-containing bases. If the five-carbon sugar is ribose, the polymer formed is called RNA; if the five-carbon sugar is deoxyribose, the polymer formed is called DNA. The difference and connection between DNA and RNA are shown in the table below.

Nucleic acid type	DNA	RNA
Structure	Regular double helix	Usually single-stranded structure
Basic unit	Deoxyribonucleotides	Ribonucleotide
Five-carbon sugar	Deoxyribose	Ribose
Nitrogenous base	Adenine(A) Guanine(G) Cytosine(C) Thymine(T)	Adenine(A) Guanine(G) Cytosine(C) Uracil(U)
Distribution location	Mainly in the nucleus while a small amount of it in mitochondria and chloroplasts	Mainly in the cytoplasm
Function	Carriers of genetic information play an extremely important role in the genetics, mutation and protein biosynthesis of organisms.	1) As the genetic material of RNA viruses. 2) In the process of DNA control protein synthesis, mRNA is a direct template for protein synthesis, tRNA can carry specific amino acids, and rRNA is a component of ribosomes. 3) A nucleic acid analog of an enzyme which has the catalytic effect.

Surface plasmon resonance (SPR) system in the analysis service of nucleic acid-related molecular interactions

DNA is the main material basis for storing, copying and transmitting genetic information. While RNA plays an important role in the process of protein synthesis. Based on the importance of DNA and RNA in physiological activities and the complexity of their functions, the detection of interactions between nucleic acids and other molecules is very necessary in biological basic analysis and detection, which is basis and prerequisite of all biological experiments.

Fig.1 The nucleic acid-related chip structure of BIAchip^TM technology platform

If your research project involves the analysis of nucleic acid-related molecular interactions, you may be able to try our SPR services. SPR system can provide high-throughput analysis for your nucleic acid-related intermolecular interaction detection, allowing parallel detection of hundreds of samples at a time. In addition, based on the high sensitivity of SPR system, it can ensure the accuracy of the final data you detect.

• Detectable nucleic acid-related molecular interaction analysis of samples based on SPR system

Using the SPR technology platform, you don't have to worry about the inapplicability of your sample format. The SPR technology platform does not require the form of the sample to be tested, which can be applied to various types of sample testing as long as you can think of. Based on the universality and flexibility of the SPR technology platform, you can perform nucleic acid-related molecular interaction analysis in the following sample forms, including antibodies, antigens, small organic molecules, bacteria, viruses, tissue lysates, serum, ascites, etc.

• Available chip types for nucleic acid-related molecular interaction analysis based on SPR system

Creative Proteomics' reliable and outstanding scientific research team will provide you with professional nucleic acid-related molecular interaction chip customization services. When we receive your nucleic acid-related molecular interaction chip customization order, immediately there will be exclusive customization experts in related fields to get in touch with you. After clarifying your project needs, our professional team will provide you with exclusive solutions within 1-2 days. We can provide you with the following nucleic acid-related molecular interaction analysis services.

If you do not find the service you are interested in, please contact us for exclusive customized services. All services of Creative Proteomics are available on a 24/7/365 basis.

For research use only. Not intended for any clinical use.