Graphene-related Interactions Analysis Service Based on SPR Technology

Graphene is a new material with a single-layer two-dimensional honeycomb lattice structure closely packed with sp² hybrid connected carbon atoms. Graphene has excellent optical, electrical, and mechanical properties, and has important application prospects in materials science, micro-nano processing, energy, biomedicine, and drug delivery. It is considered a revolutionary material in the future. Graphene itself usually has some inherent shortcomings, such as hydrophobicity, zero band gap, and chemical stability. As shown in the figure below, it is often necessary to process the original graphene into the following form. These structural morphologies include graphene nanopores (GNP), graphene nanoribbons (GNR), graphene oxide (GO), reduced graphene oxide (rGO), and graphene nanoparticle hybrid materials (G-NP). The transformation of shape and structure allows graphene to have better functions and can be more widely used in basic biochemical research.

Fig.1 Different types and forms of graphene (Wu, X, et al., 2018)

Based on the structural particularity of graphene and its derivatives, some special structures will be produced when it interacts with other molecules.

• For example: Interaction between graphene oxide and protein

Graphene oxide can be combined with proteins, and its special structure can increase the water-repellent protection of the adsorbed proteins. Protein will slowly hydrolyze over time and lose its function and activity. Once combined with graphene oxide, the rate of protein hydrolysis will slow down, which can maintain biological activity for a longer time. Preventing the target protein from being hydrolyzed is the basis of the protein delivery system, because the integrity of the protein needs to be ensured during the delivery process. Therefore, graphene oxide can be used as an effective protein delivery platform. Proteins are adsorbed on the surface of graphene oxide mainly through hydrophobic-hydrophobic interactions, which are specifically manifested as the interaction between the hydrophobin side and the hydrophobic carbon lattice. In addition, graphene oxide may also be covalently coupled with proteins and other substances on the surface of its structure. Through covalent coupling, the bonding strength between graphene oxide and protein is enhanced, maximizing their stability under different temperature, pH, organic solvents and other storage conditions.

Based on this, the various properties of the graphene oxide surface help to improve cell adhesion and adhesion. After adding graphene oxide, the cell proliferation ability in cell culture is enhanced. In the field of biomedicine, it is very suitable for human tissue engineering.

Surface plasmon resonance (SPR) technology in the analysis service of graphene-related molecular interactions

At present, based on unique biological, physical, chemical and other characteristics, graphene and its derivatives can be widely used in biomedicine. Graphene has an irreplaceable role in the field of biomedicine. As we can see in the following picture, these studies on graphene are inseparable from the analysis of the interaction between graphene and other molecules, such as DNA, proteins, and small molecules. Because graphene-related interaction analysis is the basis of graphene research, it can determine the progress of graphene research.

Fig.2 BIAchip™ in the process of graphene-related molecular interactions analysis services

SPR technology can provide high-throughput analysis of graphene-related interactions here, thereby greatly saving your analysis time. After using our SPR technology platform, your research project will no longer be complicated and time-consuming. In addition, due to the high throughput of SPR technology, the repeatability of your experiments is guaranteed, which can provide you with more opportunities to try. In addition, the sensitivity and accuracy of SPR technology provide guarantee for the data results of your graphene-related interaction analysis. On the one hand, the sensitivity reduces the detection limit. On the other hand, accuracy reduces the system error to a minimum or none. In the analysis of graphene-related interactions, you can completely trust the services that our SPR technology platform provides for you.

• Available chip types for graphene-related molecular interaction analysis based on SPR

The confidence to provide you with professional services comes from Creative Proteomics' outstanding and excellent team of experts. In every field of biology, you can get one-on-one consulting services from experts in that field. For example, for your graphene-related orders, we will provide you with exclusive customized services that match experts in the graphene field. After fully understanding your research needs, you will get customized feedback from experts within 1-2 days. Regarding graphene-related interaction analysis, Creative Proteomics mainly provide the following services.

If you do not find the service you are interested in, please contact us for exclusive customized services. All services of Creative Proteomics are available on a 24/7/365 basis.

For research use only. Not intended for any clinical use.