Cancer Target Analysis Service Based on SPR Technology

Targeted therapy helps to stop the growth and spread of cancer by targeting specific genes or proteins. These genes and proteins are found in cancer cells, or in cells associated with cancer growth. The advantage of targeted therapy is that when the drug enters the body it specifically selects the oncogenic site to combine to cause the specific death of the tumour cells without affecting the normal tissue cells surrounding the tumour. The main difference between conventional chemotherapy and targeted therapy is that targeted therapy is directed at specific molecular targets associated with cancer and does not affect the function of normal cells, whereas chemotherapy targets rapidly dividing cells, which can kill cancer cells but can also accidentally damage normal cells. Targeted therapy for cancer is the trend and will be the hottest cancer treatment in the future.

Fig.1 Categories of cancer targets (Hahn, W. C.; et al, 2021)

As shown in the figure above, recent studies have identified an expanded universe of cancer targets that include both tumor intrinsic targets and extrinsic targets including components of the TME. Among growing number of emerging targets (in purple), the concept of oncogenic cell states captures the multi-dimensional complexity of a tumor with dynamic transition states, underlying regulatory mechanisms, and subpopulation-dependent plasticity that defines cellular phenotype and therapeutic response. These new targets are the consequence of tumor heterogeneity and represent non-oncogene-dependent cancer vulnerabilities, which inform new types of therapeutic opportunities.

Surface plasmon resonance (SPR) in the process of cancer target analysis

Mechanistic studies of cancer targets and target screening occupy an important position in biological research due to the important role of cancer target analysis in cancer-related drug development. Targeted therapies for cancer have more superior properties compared to conventional therapies, and research targeting targeted therapies will be increasingly promoted. The mechanistic study of cancer targets is inseparable from the analysis of molecular interactions. The analysis of molecular interactions has important applications in identifying sites and improving ideas for the design of relevant targeting drugs. Here, Creative Proteomics offers the SPR technology platform to provide high-throughput protein-related interaction analysis services for your ion channel-related experimental projects. the general service flow and content of the SPR technology platform are as follows, and we especially recommend you to consider our technology platform if you have cancer target-related research.

Fig.2 BIAchip™ in the process of cancer target analysis

With the high throughput and accuracy of intermolecular interaction analysis offered by our SPR technology platform, you can perform the following relevant studies.

• For exploration of cancer targets mechanism

Examples of channels are located on the surface of biological membranes and are primarily responsible for the exchange of material between the extracellular and intracellular compartments. These substances include mainly biological macromolecules such as proteins and sugars, small molecule compounds and cellular metabolic waste. So the process of studying the mechanisms for ion channels involves the analysis of the interactions between proteins and various types of substances. SPR technology not only allows for a wide range of samples to be analysed, but the advantages of high throughput minimise your analysis time when faced with large volumes and multiple types of analysis.

• For research on cancer mechanisms

Based on the regulatory role of ion channels in their important metabolic functions, the study of relevant disease mechanisms also needs to start with the most basic ion channels. At the molecular level, the inactivation or disruption of ion channel transporter proteins affects the normal metabolic processes of cells. At the macroscopic level, this results in diseases of the living body. The SPR technology platform therefore enables the analysis of protein-related interactions at the molecular level to help you study the mechanisms of relevant diseases.

• For development of cancer target drug

The important purpose of disease mechanism exploration is to provide ideas for the design and development of relevant drugs and to guide downstream research. High throughput protein-related interaction analysis is able to drive the drug development process through an efficient service that not only saves you time, but also reduces costs accordingly.

With so many significant advantages for molecular interaction analysis during target screening, why not try our SPR technology platform? Once you have placed your order, Creative Proteomics will arrange for you to receive a tailor-made service from our experts in target screening field. All services are available on a 24/7/365 basis. If you have any questions or suggestions about our SPR services, please feel free to contact us right now.

For research use only. Not intended for any clinical use.